Diaclone Biologically Active Antibodies

 

Investigate your cellular assay systems using the Diaclone range of Biologically Active Monoclonal Antibodies.

Diaclone offers a broad range of biologically active, Azide Free antibodies suitable for induction, activation, neutralisation and inhibition studies

 

 

 

 

 


 

 

 

Available Biologically Active Antibodies

Specificity
(Anti-Human)
Clone Azide Free Biological Activity
CD10 B-E3 854.090.000 Cytotoxic In association with rabbit complement on CD10+ cells
CD102 / ICAM-2 B-T1 852.760.000 Inhibits cell adhesion and T-cell activation
CD106 / VCAM-1 B-K9 852.770.000 Inhibits cell attachment to VCAM-1
CD117 / c-kit B-K15 854.510.000 Inhibits the KIT ligand induced proliferation of TF1 cell line
CD126 / IL-6R B-R6 852.030.000 Inhibits IL-6 induced proliferation of XG-1 cells
CD130 / gp130 B-P8 852.080.000 Inhibits CNTF activity and binding to gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation
CD130 / gp130 B-K5 852.070.000 Inhibits CNTF activity. Inhibits OSM binding to gp130
CD130 / gp130 B-R3 852.060.000 Inhibits IL-6, IL-11, CNTF, LIF and OSM activities
CD130 / gp130 B-S12 852.110.000 Activates cells carrying gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation
CD130 / gp130 B-P4 852.090.000 Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities
CD178/FAS-L B-R17 853.070.000 Inhibits soluble CD178 induced apoptosis
CD184 B-R24 854.600.000 Inhibits HIV-1 infection
CD2 / LFA-2 B-E2 852.500.000

Inhibits mixed lymphocyte culture

CD20 B-H20 854.150.000 Cytotoxic in association with complement on CD20 cells
CD202b / Tie-2 / TEK B-B48 854.710.000 Inhibits Tek-L / Tek binding
CD21 B-E5 854.160.000 Induces human B-cell proliferation and competes with EBV for CD21 binding
IL-18Ra B-E43 854.900.000 Inhibits human IFNγ secretion induced by IL-18 stimulated cells
IL-18Rb B-B46 854.910.000 Inhibits human IFNγ secretion induced by IL-18 stimulated cells
CD25 / IL-2R B-F2 852.010.000

Inhibits mixed lymphocyte culture

CD25 / IL-2R B-B10 852.000.000

Inhibits mixed lymphocyte culture

TRAIL / APO2L B-T24 853.090.000 Inhibits TRAIL induced apoptosis
TRAIL B-S23 853.080.000 Enhances TRAIL induced apoptosis
TRAIL R1 / DR4 B-N36 854.850.000 Neutralizes TRAIL induced apoptosis on HEL cell line
TRAIL R2 / DR5 B-D37 854.870.000 Agonist: induced apoptosis on Jurkat cells. Enhances TRAIL induced apoptosis of U937 cell line
TRAIL R2 / DR5 B-K29 854.860.000 Neutralizes TRAIL induced apoptosis of U937 cell line
TRAIL R3 / DcR1 B-D44 854.890.000 Inhibits TRAIL binding to TRAIL R3
CD28 B-T3 854.220.000 Inhibits mixed lymphocyte culture. Co-stimulates T-cell proliferation.
CD3 B-B11 854.010.000 Induces T lymphocyte stimulation and proliferation
CD34 Class I B-G25 854.240.000 Triggers KG-1a cell aggregation
CD4 B-A1 854.030.000

Inhibits mixed lymphocyte culture

CD40 B-B20 854.280.000 Stimulates B-cell proliferation together with IL-4
CD44 / PGP-1 B-F24 852.600.000

Triggers T-lymphocyte aggregation. Enhances Hyaluronan binding to CD44

CD54 B-H17 852.690.000 Inhibits PHA stimulated T-cell proliferation
CD86 B-T7 854.450.000

Inhibits mixed lymphocyte culture

CD95 / FAS B-D29 853.030.000 Inhibits FasL induced apoptosis
CD95 / FAS B-G27 853.000.000 Triggers Fas induced apoptosis
HLA Class I W6/32 857.220.000 Inhibits the interaction between T cells and MHC molecules
IFN gamma B-B1 855.000.005 Inhibits IFNγ induced proliferation
IL-10 B-S10 855.100.005 Inhibits IL-10 induced proliferation on MC/9 cell line
IL-12p35+p70 B-T21 855.120.005 Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes
IL-12p40+p70 B-P24 855.130.005 Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes
IL-13 B-B13 855.140.005 Inhibits IL-13 induced proliferation on TF1 cell line
IL-15 B-E29 855.220.005 Inhibits IL-15 induced proliferation on Kit 225 cell line
IL-17A B-B51 853.910.005 Inhibits the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of defensin-2 production)
IL-17F B-F60 855.360.005 Neutralises the bioactivity of IL-17F on HT1080 cell line (measurement of IL-6 production)
IL-1beta B-A15 855.010.005 Inhibits IL-1β induced proliferation on D10S murine cell line
IL-2 B-G5 855.020.005 Inhibits IL-2 induced proliferation on CTL-L2 murine cell line
IL-23 B-Z23 853.920.005 Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production)
IL-4 B-S4 855.030.005 Inhibits IL-4 induced proliferation on TF1 cells
IL-6 B-E8 855.050.005 Inhibits IL-6 induced proliferation on B9 cells
IL-8 B-K8 855.080.005 Inhibits IL-8 induced chemotaxis of human neutrophils
NKp46 B-L46 855.490.000 Measured by the ability of the coated antibody to induce degranulation of activated NK cells and to enhance IFNγ secretion by non-activated NK cells
Neurotensin B-N6 857.040.000 Inhibits neurotensin binding to its receptor
TNF alpha B-C7 855.150.005 Inhibits TNFα induced cytotoxicity on U937 cells

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