- Catalogue N°
- 854.450.000 - 200µg / 200µl
854.450.005 - 500µg / 500µl
- Target species
- Recognises the B7.2, B70 antigen, a 80 kDa protein
- Flow Cytometry
- Functional assay
- Myeloma X63/AG.8653 x Balb/c spleen cells
- B70 transfected P815 cell line
- 200µg or 500µg (Discovery Size also available please enquire)
- Mouse IgG1 Kappa light chain
- Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
- Biological Activity
- Inhibits mixed lymphocyte culture
CD86 (also known as B7-2) is a transmembrane glycoprotein member of the IgG superfamily. CD86 is expressed on antigen-presenting cells that provide co-stimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 (B7-1) to prime T cells and its co-stimulatory pathway plays an important role in the development of anti-tumour response.
Some studies have shown that CD86 expression by malignant cells is associated with a poor prognosis in both acute myeloid leukemia and multiple myeloma and a decrease of CD86 on PBM in melanoma results in an ineffective immune response.
A high level of soluble CD86 in plasma was described in several diseases: abdominal aortic aneurysm, leukaemia, systemic lupus erythematosus and acute asthma.
Version 8 - 05.21
For research use only
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