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  New Diaclone Mini-Catalogue!

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New Antibodies

January 2020

Anti-Human IL-28A B-H44 Azide Free    857.640.000 / 857.640.005

Anti-Human IL-28A B-Z28 Azide Free    857.660.000 / 857.660.005

Anti-Human IL-28B B-L48 Azide Free    857.680.000 / 857.680.005

IL-28A, IL-28B, and IL-29, also named interferonλ2 (IFNλ2), IFNλ3, and IFNλ1, respectively, are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and the type I IFN family (15-19% aa sequence identity). The expression of IL-28A, B, and IL-29 is induced by virus infection or double stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and upregulation of MHC class I antigen expression. They signal through the same heterodimeric receptor complex that is composed of the IL10 receptor β (IL10Rβ) and a novel IL28 receptor α (IL28 Rα, also known as IFNλR1).

The three proteins have been reported to have an anti-proliferative and antitumor activity.


Anti-Human IL-17C B-A60 Azide Free    857.670.000 / 857.670.005

Anti-Human IL-17C B-Z17 Azide Free    857.710.000 / 857.710.005

The IL-17C belongs to IL-17 family including also IL17A, IL-17B, IL-17D, IL-17E (IL-25) and IL-17F which all members have a similar protein structure. IL-17C is up-regulated during inflammation and is detected in lung and skin tissues after infection by mycoplasma pneumoniae and Staphylococcus aureus and in psoriatic skin lesions. Even if IL-17C has been reported to induce the expression of proinflammatory cytokines, its biological function is still largely unexplored. It has been found that IL-17C is an epithelial cell–derived cytokine which seems to play a role equivalent to IL-17A as promoting protective antibacterial immune responses at epithelial surfaces but may also have pathological functions in diseases such as psoriasis, in which the epithelial barrier is dysfunctional.


Anti-Human I-TAC B-S40 Azide Free    857.700.000 / 857.700.005

Anti-Human I-TAC B-K43  Azide Free    857.650.000 / 857.650.005

I-TAC (for interferon-inducible T-cell alpha chemoattractant) is a small cytokine belonging to the CXC chemokine family that is also called C-X-C motif chemokine 11 and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.

CXCL9, -10, -11 have proven to be valid biomarkers for the development of heart failure and left ventricular dysfunction and it was also described than CXCL10 and CXCL11 as useful diagnostic biomarkers for acute GVHD and chronic GVHD.


Anti-Human CD38 B-E60 Azide Free    857.920.000 / 857.920.005

CD38 is an enzyme involved in synthesis and hydrolysis of cyclic ADP-ribose (cADPR), essential for the regulation of intracellular Ca2+. It is also a cell activation marker. A loss of its function is associated with impaired immune responses or metabolic disturbances.

The CD38 is a type II transmembrane glycoprotein highly expressed in hematological malignancies including multiple myeloma (MM) and represents a promising target for mAb-based immunotherapy.


Anti-Human Galectin-8 B-S36 Azide Free    857.690.000  / 857.690.005

The galectin-8 is a 25KD membrane protein, and as all members of galectins family, it is a beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. Galectin-8 is also known as prostate carcinoma tumor antigen 1 (PCTA1) in human. Various studies showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues. Due to its dual effects on the adhesive properties of cells and its association with fibronectin, galectin might be considered as a novel type of a matricellular protein. The soluble form of Galectin-8 can inhibit cell adhesion.


September 2019

Anti-Human Galectin-9 Capture Antibody - 879.990.001

Anti-Human Galectin-9 Detection Antibody - 879.990.002

Galectins is a family of non-classically secreted, β-galactoside-binding proteins that has recently received considerable attention.

Recent studies have uncovered additional mechanisms by which T cell immunoglobulin mucin-3 (TIM-3), a receptor for galectin-9, negatively regulates T cell responses by promoting CD8+ T cell exhaustion and inducing expansion of myeloid-derived suppressor cells. These mechanisms are involved in tumor growth and escape from immunity. In many solid cancers, the loss of galectin-9 expression is closely associated with metastatic progression, and treatment with recombinant galectin-9 prevents metastatic spread in various preclinical cancer models.


Anti-Human IL-34 Capture Antibody -  879.120.001

Anti-Human IL-34 Detection Antibody - 879.120.002

IL-34 has been first described in 2008 as a cytokine that plays a role in macrophage differentiation and proliferation.

IL-34 has been implicated in some disease processes. For example, the role for IL-34 in rheumatoid arthritis (RA) has been evaluated. Joint fluid levels of IL-34 are increased in RA patients compared to controls with osteoarthritis. IL-34 expression levels in synovial membrane and joint fluid correlate with inflammation severity. In vitro, in the presence of TNF (and to a lesser degree of IL-1b or IL-17), rheumatoid synoviocytes produce IL-34 (whereas synoviocytes from osteoarthritic joints do not). Serum IL-34 levels are elevated in patients with RA.


January 2019

Anti-Human RANTES Clone B-C53 Azide Free    857.600.005

Anti-Human RANTES Clone B-R46 Azide Free    857.610.005

RANTES (regulated on activation, normal T cell expressed and secreted) or chemokine (C-C motif) ligand 5 (also CCL5) is a chemotactic cytokine which in humans is encoded by the CCL5 gene.

It is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of IL-2 and IFN-γ released by T cells, CCL5 induces the proliferation and activation of certain natural-killer (NK) cells. It is also an HIV-suppressive factor released from CD8+ T cells.


Anti-Human EpCam Clone B-K46 Azide Free         857.625.000

Anti-Human EpCam Clone B-P43 Azide Free         857.626.000

Epithelial cell adhesion molecule (EpCAM) is composed of a 242 amino acid (aa) extracellular domain with two epidermal growth factor like (EGF-like) repeats, a 23 aa transmembrane domain, and a 26 aa cytoplasmic domain. It is involved in cell signaling, migration, proliferation, and differentiation.

Additionally, new discoveries were done on exosomes, which are not only “lost” membranes but are also a real communication way between cells, different than cytokines or chemokines. Their typical markers are tetraspanins like CD9, CD63 and CD81 and EpCam. It has been shown that the exosomes are secreted by tumor cells, expressing tumor antigens, could be implicated in the tumor immune evasion, and can be used as a diagnostic marker for various cancers.


Anti-Porcine FSH Clone B-F52 Azide Free    857.620.005

Anti-Porcine FSH Clone B-F52 Biotin            857.624.010

FSH is a 35.5 kDa glycoprotein heterodimer, composed of non-covalently linked glycosylated alpha and beta chains. The alpha subunit, about 96 amino acids, is common of Luteinizing Hormone (LH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin while the beta subunits vary. Both subunits are required for biological activity. FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor.

Porcine FSH is used in veterinarian medicine to enhance ovulation of cows.


Anti-Human CD146 Clone B-T46 Azide Free           857.630.000

Anti-Human CD146 Clone B-T46 Unconjugated     857.633.020
 

CD146, first reported in malignant melanomas, is a 113-kD membrane glycoprotein that contains five immunoglobulin-like domains, a transmembrane region, and a short cytoplasmic tail. The CD146, expressed in normal tissues, is restricted to the blood vessels and smooth muscle cells. Additionally, it participates in several physiological and pathological processes involving in development, immunity, and angiogenesis and has been also found to play a critical role in cancer where it promotes cancer progression, enhances migration and invasion in melanoma, gallbladder adenocarcinoma, breast and prostate cancers.

The CD146 is also named M-CAM (melanoma cell adhesion molecule).


 

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