New Diaclone Mini-Catalogue! Click and discover...
Anti-Human RANTES Clone B-C53 Azide Free 857.600.005
Anti-Human RANTES Clone B-R46 Azide Free 857.610.005
RANTES (regulated on activation, normal T cell expressed and secreted) or chemokine (C-C motif) ligand 5 (also CCL5) is a chemotactic cytokine which in humans is encoded by the CCL5 gene.
It is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of IL-2 and IFN-γ released by T cells, CCL5 induces the proliferation and activation of certain natural-killer (NK) cells. It is also an HIV-suppressive factor released from CD8+ T cells.
Anti-Human EpCam Clone B-K46 Azide Free 857.625.000
Anti-Human EpCam Clone B-P43 Azide Free 857.626.000
Epithelial cell adhesion molecule (EpCAM) is composed of a 242 amino acid (aa) extracellular domain with two epidermal growth factor like (EGF-like) repeats, a 23 aa transmembrane domain, and a 26 aa cytoplasmic domain. It is involved in cell signaling, migration, proliferation, and differentiation.
Additionally, new discoveries were done on exosomes, which are not only “lost” membranes but are also a real communication way between cells, different than cytokines or chemokines. Their typical markers are tetraspanins like CD9, CD63 and CD81 and EpCam. It has been shown that the exosomes are secreted by tumor cells, expressing tumor antigens, could be implicated in the tumor immune evasion, and can be used as a diagnostic marker for various cancers.
Anti-Porcine FSH Clone B-F52 Azide Free 857.620.005
Anti-Porcine FSH Clone B-F52 Biotin 857.624.010
FSH is a 35.5 kDa glycoprotein heterodimer, composed of non-covalently linked glycosylated alpha and beta chains. The alpha subunit, about 96 amino acids, is common of Luteinizing Hormone (LH), Thyroid-Stimulating Hormone, and Chorionic Gonadotropin while the beta subunits vary. Both subunits are required for biological activity. FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor.
Porcine FSH is used in veterinarian medicine to enhance ovulation of cows.
Anti-Human CD146 Clone B-T46 Azide Free 857.630.000
Anti-Human CD146 Clone B-T46 Unconjugated 857.633.020
CD146, first reported in malignant melanomas, is a 113-kD membrane glycoprotein that contains five immunoglobulin-like domains, a transmembrane region, and a short cytoplasmic tail. The CD146, expressed in normal tissues, is restricted to the blood vessels and smooth muscle cells. Additionally, it participates in several physiological and pathological processes involving in development, immunity, and angiogenesis and has been also found to play a critical role in cancer where it promotes cancer progression, enhances migration and invasion in melanoma, gallbladder adenocarcinoma, breast and prostate cancers.
The CD146 is also named M-CAM (melanoma cell adhesion molecule).