Anti-Human IL-17A Azide Free

Product Specifications

Catalogue N°

853.910.000 - 200µg / 200µl
853.910.005 - 500µg / 500µl

Target species

Human

Specificity

Recognizes both recombinant and natural human IL-17A

Clone

B-B51

Application

ELISA

Functional assay

ELISpot

Hybridoma

Myeloma X63/AG.8653 x Balb/c node cells

Immunisation

Recombinant human IL-17A

Quantity

200µg or 500µg (Discovery Size also available please enquire)

Isotype

Mouse IgG2b Kappa light chain

Format

Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Storage

Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Biological Activity

Inhibits the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of defensin-2 production)

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BACKGROUND

Interleukin-17 (IL-17, or IL-17A) is the founding member of a group of cytokines called the IL-17 family. IL-17A, was originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993.

IL-17A is involved in inducing and mediating proinflammatory responses, commonly associated with allergic responses and induces the production of many other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α and MCP-1) and prostaglandins (e.g. PGE2) from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages).

IL-17A function is also essential to a subset of CD4+ T-Cells called T helper 17 (Th17) cells.

Version 9 - 05.21

For research use only

Documents

• Safety Data Sheet Mab Azide Free

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