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Anti-Human CD117 Azide Free

Product Specifications

Catalogue N°
854.510.000 - 200µg / 200µl
854.510.005 - 500µg / 500µl
Target species
Recognises the Stem Cell Factor Receptor, SCF R, c-kit, a 145 kDa protein
Flow Cytometry
Functional assay
Myeloma X63/AG.8653 x Balb/c spleen cells
Recombinant c-kit
200µg or 500µg (Discovery Size also available please enquire)
Mouse IgG1 Kappa light chain
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Inhibits the KIT ligand induced proliferation of TF1 cell line
Anti-Human CD117 Azide Free
A typical staining pattern with the B-K15 monoclonal antibody of TF1 cell line


Mast / stem cell growth factor receptor (SCFR), also known as the proto-oncogene c-Kit, tyrosine protein kinase Kit or CD117, is a protein encoded in humans by the KIT1 gene located on human chromosome 4 . Multiple transcription variants encoding different isoforms have been found for this gene2. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cell homologue of the feline sarcoma viral oncogene v-kit3.

CD117 is a cytokine receptor (en) expressed on the surfaces of hematopoietic stem cells as other cell types. Altered forms of this receptor may be associated with certain types of cancer5. CD117 is a receptor with tyrosine kinase type III activity that binds Stem Cell Factor (a stem cell growth factor, belonging to the cytokine family), also known in English as "steel factor" or "c -Ligand kit ". When this receptor binds the stem cell factor (SCF), it then forms a protein dimer (en) that activates its intrinsic protein kinase activity, which in turn phosphorylates and activates signal transduction molecules that propagate this signal into the cell. CD117 signal transduction plays a role in cell survival, proliferation and differentiation.

Version 7 - 06.19

For research use only


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Formats Available

854.510.000 200µg / 200µl
854.510.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human CD117 Azide Free 854.510.000 - 200µg / 200µl 854.510.005 - 500µg / 500µl )

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