Recognises both natural and recombinant human IL-13
Clone
B-B13
Application
ELISA
Flow Cytometry
Functional assay
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human IL-13
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Inhibits IL-13 induced proliferation on TF1 cell line
Graph 1: TF1 cells proliferation measurement with resazurin after 4 days with IL-13 (6 ng/mL) and different concentrations of antibodyGraph 2: CD4+ activated by PMA and ionomycine then marked with B-B13 on intracytoplasmic stainingGraph 3: B-B13 with non-activated CD4+
IL-13 was first identified for its effects on B cells and monocytes, where it regulated class II expression, which triggered a changing IgE class, and prevented inflammatory cytokine production. It was also considered to be functionally redundant with IL-4. However, studies with conversion mice, neutralized antibodies and new reactors show that IL-13 has some unique functions that distinguish it from IL-4. Most gastrointestinal nematodes are resistant to intervention by type 2 cytokine responses, where IL-13 plays a leading role. By regulating exemption from cell intervention, IL-13 modifies intrallular organism resistance, including Leishmania major, Leishmania mexicana and Listeria monocytogenes. In the lungs, IL-13 is the central intermediary associated with allergic asthma, regulating eosinophilic inflammation, mucus secretion and sensitivity of airways. A particular cancer such as chronic lymphocytic leukemia B and Hodgkin's disease may involve the treatment of IL-13 efficiency function, where IL-13 modifies apoptosis or tumor cell growth. IL-13 can stay tumor surveillance. Accordingly, IL-13 inhibitors can be effective as anti-cancer anti-immunization by improving the anti-tumor type 1 protections. in scistosomiasis and asthma, indicating that it is the main controller of the effluent matrix. The mechanisms governing the production and / or function of IL-13, as well as IL-4, IL-12, IL-18, IFN-gamma, IL-10, TGF-beta, TNF-alpha and IL-4 were also studied. . The IL-13 receptor complex plays an important role. This review illustrates the efficiency functions of IL-13 and describes various ways of modifying its in vivo activity.
For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.
Formats Available
855.140.000 200µg / 200µl
855.140.005 500µg / 500µl
Ordering options
Place an order by phone: +33 (0)3 81 41 38 38
or by email: info
[at]
diaclone [dot] com
(
Subject: Diaclone's order,
Body: Anti-Human IL-13 Azide Free
855.140.000 - 200µg / 200µl
855.140.005 - 500µg / 500µl
)
