- Catalogue N°
- 855.140.000 - 200µg / 200µl
855.140.005 - 500µg / 500µl
- Target species
- Recognises both natural and recombinant human IL-13
- Flow Cytometry
- Functional assay
- Myeloma X63/AG.8653 x Balb/c spleen cells
- Recombinant human IL-13
- 200µg or 500µg (Discovery Size also available please enquire)
- Mouse IgG1 Kappa light chain
- Phosphate-buffered saline. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
- Biological Activity
- Inhibits IL-13 induced proliferation on TF1 cell line
IL-13 was first identified for its effects on B cells and monocytes, where it regulated class II expression, which triggered a changing IgE class, and prevented inflammatory cytokine production. It was also considered to be functionally redundant with IL-4. However, studies with conversion mice, neutralized antibodies and new reactors show that IL-13 has some unique functions that distinguish it from IL-4. Most gastrointestinal nematodes are resistant to intervention by type 2 cytokine responses, where IL-13 plays a leading role. By regulating exemption from cell intervention, IL-13 modifies intrallular organism resistance, including Leishmania major, Leishmania mexicana and Listeria monocytogenes. In the lungs, IL-13 is the central intermediary associated with allergic asthma, regulating eosinophilic inflammation, mucus secretion and sensitivity of airways. A particular cancer such as chronic lymphocytic leukemia B and Hodgkin's disease may involve the treatment of IL-13 efficiency function, where IL-13 modifies apoptosis or tumor cell growth. IL-13 can stay tumor surveillance. Accordingly, IL-13 inhibitors can be effective as anti-cancer anti-immunization by improving the anti-tumor type 1 protections. in scistosomiasis and asthma, indicating that it is the main controller of the effluent matrix. The mechanisms governing the production and / or function of IL-13, as well as IL-4, IL-12, IL-18, IFN-gamma, IL-10, TGF-beta, TNF-alpha and IL-4 were also studied. . The IL-13 receptor complex plays an important role. This review illustrates the efficiency functions of IL-13 and describes various ways of modifying its in vivo activity.
Version 9 - 06.19
For research use only
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