- Catalogue N°
- 852.690.000 - 200µg / 200µl
852.690.005 - 500µg / 500µl
- Target species
- Recognises the Intercellular Adhesion Molecule-1 (ICAM-1), a 75-115 kDa protein
- Flow Cytometry
- Functional assay
- Myeloma X63/AG.8653 x Balb/c spleen cells
- Activated human umbilical vein endothelial (HUVEC)
- 200µg or 500µg (Discovery Size also available please enquire)
- Mouse IgG1 Kappa light chain
- Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
- Biological Activity
- Inhibits PHA stimulated T-cell proliferation
ICAM-1 (InterCellular Adhesion Molecule) or CD54 is a protein encoded by the human ICAM1 gene located on human chromosome 19. It is present on the surface of endothelial cells and lymphocytes. It can serve as a receptor for viruses of the genus rhinovirus.
The protein encoded by this gene is a type of continuous intercellular adhesion molecule present at low concentrations in leukocyte membranes and endothelial cells. During cytokine stimulation, the concentrations increase considerably. When activated, leukocytes bind to endothelial cells via ICAM-1 / LFA-1 and then transmigrate into tissues.
Version 8 - 06.19
For research use only
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