Search for products

Anti-Human CD261 Azide Free

Product Specifications

Catalogue N°
854.850.000 - 200µg / 200µl
854.850.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises a 43-46 kDa protein
Clone
B-N36
Application
ELISA
Flow Cytometry
Functional assay
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL R1/Fc chimera
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free
Workshop
VIII
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Neutralizes TRAIL induced apoptosis on HEL cell line
Synonym
DR4
TRAIL R1

BACKGROUND

Human TRAIL R1/DR4, CD261 or DR4 (Death Receptor 4) is a TNF receptor, which is a receptor for TRAIL (APO2 ligand). TRAIL R1 is involved in apoptosis. In the TRAIL receptor family, TRAIL R1, but also TRAIL R2 (DR5) transduce an apoptosis signal, whereas TRAIL R3 (DcR1) and TRAIL R4 (DcR2) antagonize TRAIL-induced apoptosis. Binding of trimeric TRAIL to TRAIL R1 induces apoptosis by oligomerization (likely to be trimerization) of the receptor. TRAIL R1 cDNA encodes a 468 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. TRAIL R1 shares 55% of its amino acid sequence with TRAIL R2. TRAIL R1 is widely expressed in normal tissue.

Version 10 - 06.19

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

854.850.000 200µg / 200µl
854.850.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email:

Please contact us to discuss bulk orders