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Human CD253 ELISA Kit

Product Specifications

Catalogue N°
850.770.048 - 1 x 48 Discovery (pre-coated)
850.770.096 - 1 x 96 (pre-coated)
850.770.192 - 2 x 96 (pre-coated)
Assay Range
93.75 pg/ml - 3000 pg/ml
Sensitivity
64 pg/ml
Target species
Human
Specificity
Recognizes both natural and recombinant soluble human Trail
Incubation
3h45
Sample Type
Serum, Plasma, Cell culture supernatant
Sample Size
100 µl
Cross Reaction
No cross reactivity with other human soluble molecules
Kit Content
Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.
Synonym
APO2L
CD253 ELISA Kit
CD253 ELISA Kit

BACKGROUND

TRAIL, TNF-Related Apoptosis-Inducing Ligand (TRAIL), is a member of the tumor necrosis factor (TNF) family, also designated as Apo-2 ligand (Apo-2L) and CD253. TRAIL is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand. It is expressed at cell surface as a transmembrane protein with an extracellular region and a homotrimeric subunit structure and also exists as a soluble form

TRAIL interacts with several receptors: two pro-apoptotic death receptors DR4 (TRAIL R1) and DR5 (TRAIL R2) and three anti-apoptotic decoy receptors DcR1 (TRAIL R3), DcR2 (TRAIL R4) and osteoprotegrin (OPG). Soluble TRAIL induces apoptosis through these death receptors in many transformed cells (lymphoid as well as non-lymphoid tumor cell lines).

Because of its role in apoptosis and its stable trimer, TRAIL was described as a potential tumor-specific cancer therapeutic.

Version 20 - 07.19

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

850.770.048 1 x 48 Discovery (pre-coated)
850.770.096 1 x 96 (pre-coated)
850.770.192 2 x 96 (pre-coated)

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