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Anti-Human CD253 Unconjugated

Product Specifications

Catalogue N°
853.083.020 - 200 tests / 2ml
Target species
Human
Specificity
Recognises the TRAIL, APO2L antigen, a 32 kDa protein
Clone
B-S23
Application
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL
Quantity
200 Tests / 2ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline with 1 % BSA and 0.09 % sodium azide
Workshop
VIII
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Working Dilution
Use 10 μl to label 106 cells or 100 μl of whole blood
Synonym
APO2L

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly


BACKGROUND

TRAIL, TNF-Related Apoptosis-Inducing Ligand (TRAIL), is a member of the tumor necrosis factor (TNF) family, also designated as Apo-2 ligand (Apo-2L) and CD253. TRAIL is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand. It is expressed at cell surface as a transmembrane protein with an extracellular region and a homotrimeric subunit structure and also exists as a soluble form.

TRAIL interacts with several receptors: two pro-apoptotic death receptors DR4 (TRAIL R1) and DR5 (TRAIL R2) and three anti-apoptotic decoy receptors DcR1 (TRAIL R3), DcR2 (TRAIL R4) and osteoprotegrin (OPG). Soluble TRAIL induces apoptosis through these death receptors in many transformed cells (lymphoid as well as non-lymphoid tumor cell lines).

Because of its role in apoptosis and its stable trimer, TRAIL was described as a potential tumor-specific cancer therapeutic.

Version 7 - 06.19

For research use only

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Formats Available

853.083.020 200 tests / 2ml

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