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Anti-Human CD253 Azide Free

Product Specifications

Catalogue N°
853.090.000 - 200µg / 200µl
853.090.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises the TRAIL, APO2L antigen, a 32 kDa protein
Clone
B-T24
Application
ELISA
Flow Cytometry
Functional assay
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free
Workshop
VIII
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Inhibits TRAIL induced apoptosis
Synonym
APO2L

BACKGROUND

TRAIL, TNF-Related Apoptosis-Inducing Ligand (TRAIL), is a member of the tumor necrosis factor (TNF) family, also designated as Apo-2 ligand (Apo-2L) and CD253. TRAIL is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand. It is expressed at cell surface as a transmembrane protein with an extracellular region and a homotrimeric subunit structure and also exists as a soluble form

TRAIL interacts with several receptors: two pro-apoptotic death receptors DR4 (TRAIL R1) and DR5 (TRAIL R2) and three anti-apoptotic decoy receptors DcR1 (TRAIL R3), DcR2 (TRAIL R4) and osteoprotegrin (OPG). Soluble TRAIL induces apoptosis through these death receptors in many transformed cells (lymphoid as well as non-lymphoid tumor cell lines).

Because of its role in apoptosis and its stable trimer, TRAIL was described as a potential tumor-specific cancer therapeutic.

Version 9 - 05.19

For research use only

Documents

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Formats Available

853.090.000 200µg / 200µl
853.090.005 500µg / 500µl

Ordering options

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Please contact us to discuss bulk orders