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Anti-Human CD253 PE Conjugated

Product Specifications

Catalogue N°
853.082.010 - 100 tests / 1ml
Target species
Human
Specificity
Recognises the TRAIL, APO2L antigen, a 32 kDa protein
Clone
B-S23
Application
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL
Quantity
100 Tests / 1ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline with 5% BSA and 0.09% sodium azide
Workshop
VIII
Storage
Stable at +2-8°C for six months after reconstitution. DO NOT FREEZE.
Working Dilution
Reconstitute with 1 ml deionised water. Use 10μl to label 106 cells or 100 μl of whole blood.
Synonym
APO2L
Anti-Human CD253 PE Conjugated
A typical staining pattern with the B-S23 monoclonal antibody of IFNa2+CD3 mAb+CD28 mAb activated lymphocytes

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly


BACKGROUND

TRAIL, TNF-Related Apoptosis-Inducing Ligand (TRAIL), is a member of the tumor necrosis factor (TNF) family, also designated as Apo-2 ligand (Apo-2L) and CD253. TRAIL is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand. It is expressed at cell surface as a transmembrane protein with an extracellular region and a homotrimeric subunit structure and also exists as a soluble form.

TRAIL interacts with several receptors: two pro-apoptotic death receptors DR4 (TRAIL R1) and DR5 (TRAIL R2) and three anti-apoptotic decoy receptors DcR1 (TRAIL R3), DcR2 (TRAIL R4) and osteoprotegrin (OPG). Soluble TRAIL induces apoptosis through these death receptors in many transformed cells (lymphoid as well as non-lymphoid tumor cell lines).

Because of its role in apoptosis and its stable trimer, TRAIL was described as a potential tumor-specific cancer therapeutic.

 

Version 13 - 09.19

For research use only

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Formats Available

853.082.010 100 tests / 1ml

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