Anti-Human CD263 Unconjugated

Product Specifications

Catalogue N°

854.893.020 - 200 tests / 2ml

Target species

Human

Specificity

Recognises DcR1 (CD263), a 75.90kDa protein

Clone

B-D44

Application

Flow Cytometry

Hybridoma

Myeloma X63/AG.8653 x Balb/c spleen cells

Immunisation

Recombinant human TRAIL R3/Fc chimera

Quantity

200 Tests / 2ml (Discovery Size also available please enquire)

Isotype

Mouse IgG1 Kappa light chain

Format

Phosphate buffered saline with 1% BSA and 0.09% sodium azide

Storage

Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Working Dilution

Use 10 μl to label 10⁶ cells or 100 μl of whole blood

Synonym

DcR1

TRAIL R3

• References
• Related products

BACKGROUND

Human Trail R3, also called DcR1, CD263, LIT, or TRID is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. In the Trail receptor family, Trail R3 (DcR1) but also Trail R4 (DcR2) antagonize TRAIL-induced apoptosis whereas Trail R1 (DR4) and Trail R2 (DR5) transduce an apoptosis signal. Trail R3 has extracellular TRAIL-binding cystein-rich domain but lacks intracellular signalling domain. Expression of Trail R3 has been shown to protect cells bearing Trail R1 and/or Trail R2 from Trail-induced apoptosis. Many tumor cell lines don’t express the decoy receptors and are therefore sensitive to TRAIL if they express Trail R1 and/or Trail R2.

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly

Version 7 - 02.18

For research use only

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