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Anti-Human CD263 Unconjugated

Product Specifications

Catalogue N°
854.893.020 - 200 tests / 2ml
Target species
Human
Specificity
Recognises DcR1 (CD263), a 75.90kDa protein
Clone
B-D44
Application
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL R3/Fc chimera
Quantity
200 Tests / 2ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate buffered saline with 1% BSA and 0.09% sodium azide
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Working Dilution
Use 10 μl to label 106 cells or 100 μl of whole blood
Synonym
DcR1
TRAIL R3

BACKGROUND

Human Trail R3, also called DcR1, CD263, LIT, or TRID is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. In the Trail receptor family, Trail R3 (DcR1) but also Trail R4 (DcR2) antagonize TRAIL-induced apoptosis whereas Trail R1 (DR4) and Trail R2 (DR5) transduce an apoptosis signal. Trail R3 has extracellular TRAIL-binding cystein-rich domain but lacks intracellular signalling domain. Expression of Trail R3 has been shown to protect cells bearing Trail R1 and/or Trail R2 from Trail-induced apoptosis. Many tumor cell lines don’t express the decoy receptors and are therefore sensitive to TRAIL if they express Trail R1 and/or Trail R2.

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly

Version 7 - 02.18

For research use only

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Formats Available

854.893.020 200 tests / 2ml

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