Human CD263 ELISA Kit

Product Specifications

Catalogue N°

850.840.048 - 1 x 48 Discovery (pre-coated)
850.840.096 - 1 x 96 (pre-coated)
850.840.192 - 2 x 96 (pre-coated)

Assay Range

0.31 ng/ml - 10 ng/ml

Sensitivity

147 pg/ml

Target species

Human

Specificity

Specific for human TRAIL R3 / DcR1

Incubation

3h45

Sample Type

Serum, Cell lysates

Sample Size

100 µl

Cross Reaction

No cross reactivity was observed with TRAIL, CD117, IL-6R, IL-2R, CD116, TRAIL R1, TRAIL R2, TRAIL R4, CD178, and Granzyme B.

Kit Content

Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.

Synonym

DcR1

TRAIL R3

• Related products

BACKGROUND

Human Trail R3, also called DcR1, CD263, LIT, or TRID is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. In the Trail receptor family, Trail R3 (DcR1) but also Trail R4 (DcR2) antagonize TRAIL-induced apoptosis whereas Trail R1 (DR4) and Trail R2 (DR5) transduce an apoptosis signal. Trail R3 has extracellular TRAIL-binding cystein-rich domain but lacks intracellular signalling domain. Expression of Trail R3 has been shown to protect cells bearing Trail R1 and/or Trail R2 from Trail-induced apoptosis. Many tumor cell lines don’t express the decoy receptors and are therefore sensitive to TRAIL if they express Trail R1 and/or Trail R2.

Version 7 - 02.22

For research use only

Documents

• Human TRAIL R3_DcR1_CD263 ELISA Kit insert
• Safety Data Sheet ELISA Kits

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