Anti-Human CD262 PE Conjugated

Product Specifications

Catalogue N°

854.862.010 - 100 tests / 1ml

Target species

Human

Specificity

Recognises a 42-46 kDa protein

Clone

B-K29

Application

Flow Cytometry

Hybridoma

Myeloma X63/AG.8653 x Balb/c spleen cells

Immunisation

Recombinant human TRAIL R2/Fc chimera

Quantity

100 Tests / 1ml (Discovery Size also available please enquire)

Isotype

Mouse IgG1 Kappa light chain

Format

Phosphate-buffered saline with 5% BSA and 0.1% sodium azide

Workshop

VIII

Storage

Stable at +2-8°C for six months after reconstitution. DO NOT FREEZE.

Working Dilution

Reconstitute with 1 ml deionised water. Use 10μl to label 10⁶ cells or 100 μl of whole blood.

Synonym

DR5

TRAIL R2

• References
• Related products

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly

BACKGROUND

Human Trail R2, also called DR5 (Death Receptor 5), CD262, TRICK 2 or Apo2 is a TNF receptor, which is a receptor for Trail (APO2 ligand). Trail R2 is involved in apoptosis. In the Trail receptor family, Trail R2, but also Trail R1 (DR4) transducer an apoptosis signal, whereas Trail R3 (DcR1) and Trail R4 (DcR2) antagonize TRAIL-induced apoptosis. Binding of trimeric Trail to Trail R1 induces apoptosis by oligomerization (likely to be trimerization) of the receptor. Trail R2 cDNA encodes a 440 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Trail R2 shares 55% of its amino acid sequence with Trail R1.Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells.

Version 10 - 06.19

For research use only

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