Human CD262 ELISA Kit

Product Specifications

Catalogue N°

850.830.048 - 1 x 48 Discovery (pre-coated)
850.830.096 - 1 x 96 (pre-coated)
850.830.192 - 2 x 96 (pre-coated)

Assay Range

31.25 pg/ml - 1000 pg/ml

Sensitivity

6 pg/ml

Target species

Human

Specificity

Specific for human TRAIL R2 / DR5

Incubation

2h45

Sample Type

Serum, Cell lysates, Cell culture supernatant

Sample Size

100 µl

Cross Reaction

No cross reactivity was observed with TRAIL, CD117, IL-6R, IL-2R, CD116, TRAIL R1, TRAIL R3, TRAIL R4, CD178 and Granzyme B.

Kit Content

Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.

Synonym

DR5

TRAIL R2

• References
• Related products

BACKGROUND

Human Trail R2, also called DR5 (Death Receptor 5), CD262, TRICK 2 or Apo2 is a TNF receptor, which is a receptor for Trail (APO2 ligand). Trail R2 is involved in apoptosis. In the Trail receptor family, Trail R2, but also Trail R1 (DR4) transducer an apoptosis signal, whereas Trail R3 (DcR1) and Trail R4 (DcR2) antagonize TRAIL-induced apoptosis. Binding of trimeric Trail to Trail R1 induces apoptosis by oligomerization (likely to be trimerization) of the receptor. Trail R2 cDNA encodes a 440 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Trail R2 shares 55% of its amino acid sequence with Trail R1.Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells.

Version 8 - 02.22

For research use only

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