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Anti-Human CD262 Azide Free

Product Specifications

Catalogue N°
854.860.000 - 200µg / 200µl
854.860.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises a 42-46 kDa protein
Clone
B-K29
Application
ELISA
Flow Cytometry
Functional assay
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL R2/Fc chimera
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
Workshop
VIII
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Neutralizes TRAIL induced apoptosis of U937 cell line
Synonym
DR5
TRAIL R2
Anti-Human CD262 Azide Free
A typical staining pattern with the B-K29 monoclonal antibody of cell line Eahy926

BACKGROUND

Human Trail R2, also called DR5 (Death Receptor 5), CD262, TRICK 2 or Apo2 is a TNF receptor, which is a receptor for Trail (APO2 ligand). Trail R2 is involved in apoptosis. In the Trail receptor family, Trail R2, but also Trail R1 (DR4) transducer an apoptosis signal, whereas Trail R3 (DcR1) and Trail R4 (DcR2) antagonize TRAIL-induced apoptosis. Binding of trimeric Trail to Trail R1 induces apoptosis by oligomerization (likely to be trimerization) of the receptor. Trail R2 cDNA encodes a 440 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Trail R2 shares 55% of its amino acid sequence with Trail R1.Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells.

Version 12 - 05.21

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

854.860.000 200µg / 200µl
854.860.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human CD262 Azide Free 854.860.000 - 200µg / 200µl 854.860.005 - 500µg / 500µl )

Please contact us to discuss bulk orders