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Anti-Human CD14 Azide Free

Product Specifications

Catalogue N°
854.110.000 - 200µg / 200µl
854.110.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises the lipopolysaccharide receptor (LPS R), a 55 kDa protein
Clone
B-A8
Application
ELISA
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Monocytes
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Anti-Human CD14 Azide Free
A typical staining pattern with the B-A8 monoclonal antibody of monocytes

BACKGROUND

CD14 is described as the marker molecule for monocytes and macrophages and as an important component of the innate immune system. It exists in two forms : mCD14 a 55 kDa protein anchored to the membrane by a glycosylphosphoinositol tail (GPI)  and two soluble serum proteins (sCD14) with or without the GPT anchor. The mCD14 is critical for lipopolysaccharide (LPS) dependent signal transduction, and sCD14 confers LPS sensitivity to cells lacking mCD14. CD14 is strongly expressed on cells of the myelomonocytic lineage such as monocytes and osteoclast progenitors and at a lower level on macrophages, Langerhans cells, granulocytes and microglia.

Increased sCD14 levels are associated with inflammatory infectious diseases or allergy.

CD14 is involved in clearance of gram-negative bacteria via its high affinity binding to LPS-LPB complexes. CD14 is a useful marker for enumeration of monocytes or osteoclast progenitors in peripheral blood and for monocytic and myelomonocytic acute myeloid leukaemia.

Version 10 - 06.19

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

854.110.000 200µg / 200µl
854.110.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human CD14 Azide Free 854.110.000 - 200µg / 200µl 854.110.005 - 500µg / 500µl )

Please contact us to discuss bulk orders