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Anti-Human CD86 FITC Conjugated

CE certified product *

Product Specifications

Catalogue N°
954.451.010 - 100 tests / 1ml
Target species
Human
Specificity
Recognises the B7.2, B70 antigen, a 80 kDa protein
Clone
B-T7
Application
Flow Cytometry
Immunohistochemistry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
B70 transfected P815 cell line
Quantity
100 Tests / 1ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline with 1 % BSA and 0.1 % sodium azide
Workshop
VI
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Working Dilution
Use 10 μl to label 106 cells or 100 μl of whole blood
Synonym
B7-2
Anti-Human CD86 FITC Conjugated
A typical staining pattern with the B-T7 monoclonal antibody of monocytes

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly


BACKGROUND

CD86 (also known as B7-2) is a transmembrane glycoprotein member of the IgG superfamily. CD86 is expressed on antigen-presenting cells that provide co-stimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 (B7-1) to prime T cells and its co-stimulatory pathway plays an important role in the development of anti-tumour response.

Some studies have shown that CD86 expression by malignant cells is associated with a poor prognosis in both acute myeloid leukemia and multiple myeloma and a decrease of CD86 on PBM in melanoma results in an ineffective immune response.

A high level of soluble CD86 in plasma was described in several diseases: abdominal aortic aneurysm, leukaemia, systemic lupus erythematosus and acute asthma.

Version 10 - 07.19

For research use only

Documents

* CE marked products are available for IVD use in the EU only. For all other regions these products are for research use only.

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

954.451.010 100 tests / 1ml

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human CD86 FITC Conjugated 954.451.010 - 100 tests / 1ml )

Please contact us to discuss bulk orders