- Catalogue N°
- 855.460.000 - 200µg / 200µl
855.460.005 - 500µg / 500µl
- Target species
- Recognises both natural and recombinant human IL-31
- Myeloma X63/AG.8653 x Balb/c node cells
- Recombinant human IL-31
- 200µg or 500µg (Discovery Size also available please enquire)
- Mouse IgG2b Kappa light chain
- Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
IL-31 is a 24 kDa α-helical protein from the IL-6 family. It is composed by 141 amino acids. It is preferentially produced by CD4+ T cells such as Th2 and expressed on activated monocytes and epithelial cells. Human and mouse IL-31 share 24% aa sequence identity in the mature region. IL-31 elicits its response by binding to a heterodimeric complex consisting of a 120 kDa gp130-like receptor chain called IL-31RA and a 180 kDa oncostatin M receptor subunit. Target cells include a broad range of immune and non-immune cells. IL-31 receptor is constitutively expressed in keratinocytes and epithelial cells and upregulated by IFNγ in monocytes. IL-31 binding can induce activation of the Jak/STAT, AKT and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response. Over-expression has been linked chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity, and inflammatory bowel disease. IL-31 is mainly involved in skin disorders but also in other allergy disease such as asthma.
Version 6 - 06.19
For research use only
For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.