Search for products

Anti-Human IL-8 Azide Free

Product Specifications

Catalogue N°
855.080.000 - 200µg / 200µl
855.080.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises both natural and recombinant human IL-8
Clone
B-K8
Application
ELISA
Flow Cytometry
Functional assay
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human IL-8
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Inhibits IL-8 induced chemotaxis of human neutrophils
Anti-Human IL-8 Azide Free
The graph on the left represents activated monocytes marked with B-K8 .
Anti-Human IL-8 Azide Free
The graph on the right shows B-K8 with non-activated monocytes. In the two cases, the dotted line represents the IgG1 isotype control.

BACKGROUND

Interleukin 8 (IL-8) or CXCL8, Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF), Neutrophil Activating Factor (NAF) and NAD-P1 is a chemokine secreted by monocytes, macrophages and endothelial cells. IL-8 chemoattracts and activates neutrophils.

The predominant form of IL-8 is a 8.4kDa protein containing 72 amino acid residues, which includes five additional N-Terminal amino-acids. IL-8 contains the four conserved cysteine residues present in CXC chemokines and also contains the “ELR” motif common to CXC chemokines that binds to CXCR1 and CXCR2.

Data indicate that IL-8 may participate in the pathogenesis of rheumatoid arthritis via the induction of neutrophil-mediated cartilage damage, and psoriasis. A causative involvement of IL-8 is found within a broad range of clinico-pathological conditions : adult respiratory distress syndrome, asthma, bacterial infections, bladder cancer, graft rejection and influenza infection, due to the now known biological properties of IL-8. This cytokine especially in combinations with other neutrophil activating agents, may prove helpful in the treatment of patients suffering from granulocytopenia, severe infections against which antibiotics are not effective, and immunodeficiency caused by HIV.

Version 11 - 06.19

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

855.080.000 200µg / 200µl
855.080.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email:

Please contact us to discuss bulk orders