- Catalogue N°
- 853.840.000 - 200µg / 200µl
853.840.005 - 500µg / 500µl
- Target species
- Recognises both natural and recombinant human IL-7
- Myeloma X63/AG.8653 x Balb/c node cells
- Recombinant human IL-7
- 200µg or 500µg (Discovery Size also available please enquire)
- Mouse IgG1 Kappa light chain
- Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Human IL-7 (Interleukin 7, IL-7) is a 177-amino acids protein encoded by the IL7 gene located on chromosome 8 (Locus 8q12-13). The active form is glycosylated, weight 25kDa and binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha (CD127) and common gamma chain receptor CD132) Interleukin-7 is a member of hematopoietic growth factor which plays a role in T-cells development and induces the growth of immature B lymphocytes. IL-7 is secreted by epithelial cells in thymus and bone marrow. It is also produced by intestinal epithelium, keratenocytes, hepatocytes and dendritics cells. It was described to regulate T cell response and proliferation in tissue and serve as a potent regulatory factor.
IL-7 is known to induce the differentiation and proliferation of some haematological malignancies including certain types of leukaemias, lymphomas and may be elevated in lymphopenia. It was also described in breast cancer, common variable immunodeficiency (CVID), HIV (originally presented as a potential eradicating agent), rheumatoid arthritis.
In invasive breast cancer, an aberrant expression of IL-7 and its signaling were described.
In CVID, an elevated plasma levels of circulating IL-7 in a subgroup of patients.
In HIV, it was described that an increase of IL-7 level, produced by dendritic-like cells, enhances a lymphocytes depletion in tissues (lymphopenia).
In RA, IL-7 in synovial fluid activates T cells and macrophages which lead to the inflammation characteristic of RA thought TNFα.
Version 6 - 06.19
For research use only
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