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Rat IL-6 ELISA Kit

Product Specifications

Catalogue N°
670.010.096 - 1 x 96 (pre-coated)
670.010.192 - 2 x 96 (pre-coated)
Assay Range
31.3 pg/ml - 2000 pg/ml
Sensitivity
12 pg/ml
Target species
Rat
Specificity
Recognizes both natural and recombinant rat IL-6
Incubation
3h15
Sample Type
Serum, Plasma, Cell culture supernatant
Sample Size
50 µl
Cross Reaction
No cross reactivity with other rat cytokines
Kit Content
Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.
rIL-6 ELISA Kit
rIL-6 ELISA Kit

BACKGROUND

Interleukin-6 (IL-6) is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis and may play a central role in host defense mechanisms.

IL-6 is usually not produced constitutively by normal cells, but its expression is readily induced by a variety of cytokines, lipopolysaccharide or viral infections.

IL-6 is a pleiotropic cytokine produced by a variety of cells. It acts on a wide range of tissues, exerting growth-induction, growth-inhibition, and differentiation respectively, depending on the nature of the target cells.

IL-6 is involved in:

- the induction of B-cell differentiation,

- the induction of acute phase proteins in liver cells,

- growth promotion of myeloma/plasmacytoma/hybridoma cells,

- induction of IL-2 and IL-2 receptor expression,

- proliferation and differentiation of T cells,

- inhibition of cell growth of certain myeloid leukemic cell lines and induction of their differentiation to  macrophages,

- enhancement of IL-3-induced multipotential colony cell formation in hematopoietic stem cells and induction of maturation of megakaryocytes as a thrombopoietic factor,

- induction of mesangial cell growth,

- induction of neural differentiation of PC 12 cells and

- induction of keratinocyte growth

The abnormal production of IL-6 was first suggested to be related to polyclonal B-cell activation with autoantibody production in patients with cardiac myxoma (2). Since then, IL-6 has been suggested to be involved in the pathogenesis of a variety of diseases. Measurement of IL-6 levels in serum and other body fluids thus provides more detailed insights into various pathological situations.

Version 3 - 07.19

For research use only

Documents

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Formats Available

670.010.096 1 x 96 (pre-coated)
670.010.192 2 x 96 (pre-coated)

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