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Murine IL-6 ELISA Set

Product Specifications

Catalogue N°
861.020.001 - 1 x 96 Discovery
861.020.005 - 5 x 96
861.020.010 - 10 x 96
861.020.015 - 15 x 96
861.020.020 - 20 x 96
Assay Range
15.6 pg/ml - 500 pg/ml
Sensitivity
10 pg/ml
Target species
Murine
Specificity
Recognizes both natural and recombinant murine IL-6
Incubation
From sample to end 3h50
Sample Type
Serum, Cell culture supernatant
Sample Size
100 µl
Cross Reaction
No cross reactivity with other murine cytokines
Kit Content
Diaclone ELISA Sets include capture and biotinylated detection antibody, one standard per plate, Streptavidin-HRP, TMB, and detailed procedure including buffer composition.

BACKGROUND

Interleukin-6 (IL-6) is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis and may play a central role in host defense mechanisms.

This cytokine is involved in :

  • the induction of B-cell differentiation,
  • the induction of acute phase proteins in liver cells,
  • growth promotion of myeloma/plasmacytoma/hybridoma cells,
  • induction of IL-2 and IL-2 receptor expression,
  • proliferation and differentiation of T cells,
  • inhibition of cell growth of certain myeloid leukemic cell lines and induction of their differentiation to macrophages,
  • enhancement of IL-3-induced multipotential colony cell formation in hematopoietic stem cells and induction of maturation of megakaryocytes as a thrombopoietic factor,
  • induction of mesangial cell growth,
  • induction of neural differentiation of PC cells
  • induction of keratinocyte growth.

The abnormal production of IL-6 was first suggested to be related to polyclonal B-cell activation with autoantibody production in patients with cardiac myxoma. Since then, IL-6 has been suggested to be involved in the pathogenesis of a variety of diseases. Measurement of IL-6 levels in serum and other body fluids thus provides more detailed insights into various pathological situations.

Version 10 - 02.20

For research use only

Documents

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Formats Available

861.020.001 1 x 96 Discovery
861.020.005 5 x 96
861.020.010 10 x 96
861.020.015 15 x 96
861.020.020 20 x 96

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