Human Perforin ELISpot Pair

Product Specifications

Catalogue N°

869.140.010 - 10 x 96 tests

Target species

Human

Specificity

Recognizes natural human Perforin

Cross Reaction

No cross reactivity with other human soluble molecules

Kit Content

Diaclone ELISpot matched antibody pairs are extensively validated and include pre-titrated capture antibody and biotinylated detection antibody. Antibodies are supplied in quantities sufficient for 10 x 96 samples.

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BACKGROUND

Perforin is a 70kDa protein containing 534 amino acid.

Perforin is involved in the killing function by CTLs and NKs. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. It leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis, the cell death program.

Perforin has structural and functional similarities to complement component 6, 7, 8 and 9 (C6, C7, C8, C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.

Its role in the immune response against tumors and virus infection has been demonstrated.

Version 6 - 04.20

For research use only

Documents

• Human Perforin ELISpot Pair insert
• Safety Data Sheet ELISpot Pairs

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.