- Catalogue N°
- 850.930.048 - 1 x 48 Discovery (pre-coated)
850.930.096 - 1 x 96 (pre-coated)
850.930.192 - 2 x 96 (pre-coated)
- Assay Range
- 4.4 ng/ml - 140 ng/ml
- 3.6 ng/ml
- Target species
- Recognizes both natural and recombinant human P-Selectin
- Sample Type
- Serum, Plasma, Cell culture supernatant, Amniotic fluid
- Sample Size
- 100 µl
- Kit Content
- Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.
P-selectin (CD62P, LECAM-3) was originally purified from platelets and later found to be expressed also in endothelial cells. In both cell types, P-selectin is constitutively expressed and stored in secretory granules – α-granules in platelets and Weibel-Palade bodies in endothelial cells.
A soluble form of P-selectin, which might represent a proteolytic fragment or a soluble splice variant lacking the transmembrane domain, is found in serum and plasma. High expression of P-selectin or sP-selectin has been implicated in several inflammatory disorders, including adult respiratory distress syndrome, acute lung injury, ischemia-reperfusion injury, Gram-negative septic shock, thrombotic diseases, malaria, systemic sclerosis, connective tissue disease and rheumatoid arthritis. Furthermore, lung injury scores correlate significantly with sP-selectin in plasma of patients with acute lung injury.
Version 14 - 02.20
For research use only
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