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Anti-Human Perforin Azide Free

Product Specifications

Catalogue N°
854.950.000 - 200µg / 200µl
854.950.005 - 500µg / 500µl
Target species
Recognizes human Perforin, a 70 kDa protein
Flow Cytometry
Western Blot
Immunohistochemistry on frozen sections
Myeloma X63/AG.8653 x Balb/c spleen cells
Natural human Perforin
200µg or 500µg (Discovery Size also available please enquire)
Mouse IgG1 Kappa light chain
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Anti-Human Perforin Azide Free
A typical staining pattern with the B-D48 monoclonal antibody of lymphocytes


Perforin is a 70kDa protein containing 534 amino acid.

Perforin is involved in the killing function by CTLs and NKs. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. It leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis, the cell death program.

Perforin has structural and functional similarities to complement component 6, 7, 8 and 9 (C6, C7, C8, C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.

Its role in the immune response against tumors and virus infection has been demonstrated.

Version 14 - 07.19

For research use only


For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

854.950.000 200µg / 200µl
854.950.005 500µg / 500µl

Ordering options

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