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Anti-Human IL-23 Azide Free

Product Specifications

Catalogue N°
853.920.000 - 200µg / 200µl
853.920.005 - 500µg / 500µl
Target species
Human
Specificity
Recognizes both recombinant and natural human IL-23, p19 sub-unit
Clone
B-Z23
Application
ELISA
Functional assay
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human IL-23 (sub-unit p19)
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production)
Anti-Human IL-23 Azide Free
Labelling on paraffin section from psoriasis lesions with B-Z23 diluted at 1:500 (background colouration by DAPI)

BACKGROUND

Interleukin-23 is a heterodimeric cytokine consisting in two subunits : p40, shared  with IL-12 and a distinct one p19 (the IL-23  subunit). Although IL-12 activates naive T cells, the initial description of IL-23 was the preferential action on memory T cells to increase IFNg production. In conjonction with IL-6 and TGF-b1, IL-23 is necessary to maintain the Th1 lineage. IL-23 plays an important role in the inflammatory response against infection, and is implicated in the developpement of cancerous tumors and auto immune diseases. Over expression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin.

Version 11 - 06.19

For research use only

Documents

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Formats Available

853.920.000 200µg / 200µl
853.920.005 500µg / 500µl

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