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Anti-Human IFN-γ PE Conjugated

Product Specifications

Catalogue N°
855.002.019 - 100 tests / 1ml
Target species
Human
Specificity
Recognises both natural and recombinant human IFN-g
Clone
B-B1
Application
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human IFN-g
Quantity
100 Tests / 1ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline with 5% BSA and 0,1% sodium azide
Storage
Stable at +2-8°C for six months after reconstitution. DO NOT FREEZE.
Working Dilution
Reconstitute with 1ml of deionized water. It is recommended to establish the optimal dilution according to the system being used. Use 10 μl of antibody to label 5.105 cells
Synonym
IFN-g
IFN-gamma
Anti-Human IFN-g PE Conjugated
A typical staining pattern with the B-B1 monoclonal antibody of PMA and ionomycin activated PBL

BACKGROUND

Interferon-gamma (IFN-γ, IFN-g, IFN gamma), also known as type II or immune interferon, is a dimerized soluble cytokine.

Interferon gamma is produced mainly by activated T cells and Natural Killer cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops. IFN gamma is also produced by non-cytotoxic innate lymphoid cells (ILC), a family of immune cells first discovered in the early 2010s

IFNg is considered to be a proinflammatory cytokine, that activates macrophages and endothelial cells, it also regulates immune responses by effecting APC, T and  cells.

 

IFN gamma is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFN gamma is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression. Aberrant IFNγ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects.

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly

Version 9 - 02.18

For research use only

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Formats Available

855.002.019 100 tests / 1ml

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