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Anti-Human IFN-γ Azide Free

Product Specifications

Catalogue N°
855.000.000 - 200µg / 200µl
855.000.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises both natural and recombinant human IFN-g
Clone
B-B1
Application
ELISA
Flow Cytometry
Immunohistochemistry
Functional assay
ELISpot
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human IFN-g
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Inhibits IFNγ induced proliferation
Synonym
IFN-g
IFN-gamma
Anti-Human IFN-γ Azide Free
The graph on the left represents activated lymphocytes marked with B-B1.
Anti-Human IFN-γ Azide Free
The graph on the right shows B-B1 with non-activated lymphocytes. In the two cases, the dotted line represents the IgG1 isotype control.

BACKGROUND

Interferon-gamma (IFN-γ, IFN-g, IFN gamma), also known as type II or immune interferon, is a dimerized soluble cytokine.

Interferon gamma is produced mainly by activated T cells and Natural Killer cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops. IFN gamma is also produced by non-cytotoxic innate lymphoid cells (ILC), a family of immune cells first discovered in the early 2010s

IFNg is considered to be a proinflammatory cytokine, that activates macrophages and endothelial cells, it also regulates immune responses by effecting APC, T and  cells.

IFN gamma is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFN gamma is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression. Aberrant IFNγ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects.

Version 9 - 05.19

For research use only

Documents

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Formats Available

855.000.000 200µg / 200µl
855.000.005 500µg / 500µl

Ordering options

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