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Anti-Human CD264 Unconjugated

Product Specifications

Catalogue N°
854.973.020 - 200 tests / 2ml
Target species
Human
Specificity
Recognises TRAIL R4 (DcR2), a 44.2 kDa protein
Clone
B-R27
Application
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL R4/Fc chimera
Quantity
200 Tests / 2ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate buffered saline with 1% BSA and 0.09% sodium azide
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Working Dilution
Use 10 μl to label 106 cells or 100 μl of whole blood
Synonym
DcR2
TRAIL R4

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly


BACKGROUND

Human Trail R4, also called DcR1, CD264 or TRUNND is a type 1 TNF R family membrane protein which is a receptor for TRAIL. In the Trail receptor family, Trail R4 (DcR2) but also Trail R3 (DcR1) antagonize TRAIL-induced apoptosis whereas Trail R1 (DR4) and Trail R2 (DR5) transducer an apoptosis signal. Trail R4 has a truncated intracellular domain.  Overexpression of Trail R4 has been shown to protect cells bearing Trail R1 and/or Trail R2 from Trail-induced apoptosis. Many tumor cell lines don’t express the decoy receptors and are therefore sensitive to TRAIL if they express Trail R1 and/or Trail R2.

Version 8 - 06.19

For research use only

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Formats Available

854.973.020 200 tests / 2ml

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