- Catalogue N°
- 852.122.010 - 100 tests / 1ml
- Target species
- Recognises the IL-13 receptor a2 (IL-13 Ra2), a 44 kDa protein
- Flow Cytometry
- Myeloma X63/AG.8653 x Balb/c spleen cells
- IL-13Ra2 transfected CHO cell line
- 100 Tests / 1ml (Discovery Size also available please enquire)
- Mouse IgG1 Kappa light chain
- Phosphate-buffered saline with 5% BSA and 0.09% sodium azide
- Stable at +2-8°C for six months after reconstitution. DO NOT FREEZE.
- Working Dilution
- Reconstitute with 1 ml deionised water. Use 10μl to label 106 cells or 100 μl of whole blood.
Sodium azide is a poisonous and hazardous substance, handle and dispose of properly
Two membrane proteins belonging to the receptor family CD213a have been identified and shown to bind IL-13 with differing affinities and different functionality.
The CD213a2 also named IL-13 R alpha 2 binds, as monomer, IL-13 with high-affinity but not IL-4. The role of IL-13 R alpha 2 in IL-13 signaling remains to be elucidated. With a small 17 aa cytoplasmic domain, unable to induce signal, it does not appear to function as a signal mediator. It could act as a decoy receptor by binding and internalizing IL‑13 and preventing it from signaling through the IL‑13 R alpha 1/IL‑4 R alpha complex
The up‑regulation of transmembrane CD213a2 during Th2‑based immune responses limits the extent of those responses. IL-13Rα2 has been found to be over-expressed also in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas.
Version 12 - 04.20
For research use only
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