Anti-Human CD213a2 PE Conjugated

Product Specifications

Catalogue N°

852.122.010 - 100 tests / 1ml

Target species

Human

Specificity

Recognises the IL-13 receptor a2 (IL-13 Ra2), a 44 kDa protein

Clone

B-D13

Application

Flow Cytometry

Hybridoma

Myeloma X63/AG.8653 x Balb/c spleen cells

Immunisation

IL-13Ra2 transfected CHO cell line

Quantity

100 Tests / 1ml (Discovery Size also available please enquire)

Isotype

Mouse IgG1 Kappa light chain

Format

Phosphate-buffered saline with 5% BSA and 0.09% sodium azide

Workshop

VII

Storage

Stable at +2-8°C for six months after reconstitution. DO NOT FREEZE.

Working Dilution

Reconstitute with 1 ml deionised water. Use 10μl to label 10⁶ cells or 100 μl of whole blood.

Synonym

IL-13Ra2

• References
• Related products

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly

BACKGROUND

Two membrane proteins belonging to the receptor family CD213a have been identified and shown to bind IL-13 with differing affinities and different functionality.

The CD213a2 also named IL-13 R alpha 2 binds, as monomer, IL-13 with high-affinity but not IL-4. The role of IL-13 R alpha 2 in IL-13 signaling remains to be elucidated. With a small 17 aa cytoplasmic domain, unable to induce signal, it does not appear to function as a signal mediator. It could act as a decoy receptor by binding and internalizing IL‑13 and preventing it from signaling through the IL‑13 R alpha 1/IL‑4 R alpha complex

The up‑regulation of transmembrane CD213a2 during Th2‑based immune responses limits the extent of those responses. IL-13Rα2 has been found to be over-expressed also in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas.

Version 12 - 04.20

For research use only

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