Anti-Human CD213a2 Azide Free

Product Specifications

Catalogue N°

853.960.000 - 200µg / 200µl
853.960.005 - 500µg / 500µl

Target species

Human

Specificity

Recognises the IL-13 receptor a2 (IL-13 Ra2), a 74 kDa protein

Clone

B-A34

Application

ELISA

Hybridoma

Myeloma X63/AG.8653 x Balb/c spleen cells

Immunisation

IL-13Ra2 transfected CHO cell line

Quantity

200µg or 500µg (Discovery Size also available please enquire)

Isotype

Mouse IgG1 Kappa light chain

Format

Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free

Storage

Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Synonym

IL-13Ra2

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BACKGROUND

Two membrane proteins belonging to the receptor family CD213a have been identified and shown to bind IL-13 with differing affinities and different functionality.

The CD213a2 also named IL-13 R alpha 2 binds, as monomer, IL-13 with high-affinity but not IL-4. The role of IL-13 R alpha 2 in IL-13 signaling remains to be elucidated. With a small 17 aa cytoplasmic domain, unable to induce signal, it does not appear to function as a signal mediator. It could act as a decoy receptor by binding and internalizing IL‑13 and preventing it from signaling through the IL‑13 R alpha 1/IL‑4 R alpha complex

The up‑regulation of transmembrane CD213a2 during Th2‑based immune responses limits the extent of those responses. IL-13Rα2 has been found to be over-expressed also in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas.

Version 6 - 04.20

For research use only

Documents

• Safety Data Sheet Mab Azide Free

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