Anti-Human CD106 Azide Free

Product Specifications

Catalogue N°

853.820.000 - 200µg / 200µl
853.820.005 - 500µg / 500µl

Target species

Human

Specificity

Recognises the Vascular Cellular Adhesion Molecule-1 (VCAM-1), a 110 kDa protein

Clone

B-S6

Application

ELISA

Flow Cytometry

Hybridoma

Myeloma X63/AG.8653 x Balb/c spleen cells

Immunisation

Activated human umbilical vein endothelial cells

Quantity

200µg or 500µg (Discovery Size also available please enquire)

Isotype

Mouse IgG1 Kappa light chain

Format

Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free

Storage

Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Synonym

VCAM-1

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BACKGROUND

The vascular cell adhesion protein 1, also known as vascular cell adhesion molecule 1 (VCAM-1) or differentiation group 106 (CD106), is a protein that in humans is coded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.

The VCAM-1 protein induces the adhesion of lymphocytes, monocytes, eosinophils and basophils to the vascular endothelium. It also plays a role in signal transduction of leukocyte-endothelial cells and may play a role in the development of atherosclerosis and rheumatoid arthritis.

Positive regulation of VCAM-1 in endothelial cells by cytokines results from increased transcription of the gene (eg, in response to tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1 )) and the stabilization of the messenger RNA. (MRNA) (e.g., interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem sites NF-KB (nuclear factor-kappa B). The sustained expression of VCAM-1 lasts more than 24 hours.

Mainly, the VCAM-1 protein is an endothelial ligand of the VLA-4 (Very Late Antigen-4 or α4β1 integrin) of the β1 integrin subfamily. VCAM-1 expression has also been observed in other cell types (eg, smooth muscle cells). It has also been shown to interact with EZR and Moesin.

CD106 also exists on the surface of certain sub-populations of mesenchymal stem cells (MSCs).

Version 6 - 06.19

For research use only

Documents

• Safety Data Sheet Mab Azide Free

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