- Catalogue N°
- 873.090.048 - 1 x 48 Discovery (pre-coated)
873.090.096 - 1 x 96 (pre-coated)
873.090.192 - 2 x 96 (pre-coated)
- Assay Range
- 31.25-1000 pg/ml
- 12.3 pg/ml
- Target species
- Recognizes both natural and recombinant human MICB
- Sample Type
- Cell culture supernatant, serum, plasma
- Sample Size
- 50µl / 100µl
- Cross Reaction
- No cross reactivity with MICA, Ang-2, IL-1b, IL-34, IL-10, IL-31, IFNg, GM-CSF, VEGF-165 and IL-2
- Kit Content
- Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.
MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within the MHC class I region of chromosome 6. Similar to MICA, MICB protein interacts with the natural killer cell receptor NKG2D and T cell receptor (TCR) and consequently activates the natural killer (NK) cells, gamma-delta (γδ) T cells and alpha-beta (αβ) CD8+ T cells, enhancing their cytolytic ability and cytokine production. Thus, the MICA/B–NKG2D pathway is an important mechanism by which the host immune system recognizes and kills transformed cells. This protein is stress and heat shock-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. It seems to have no role in antigen presentation.
In contrast to classical MHC class I molecules, MICA/B are expressed rarely on normal cells but frequently on tumor cells, including colon cancer, prostate cancer, hepatocellular carcinoma, and brain tumors. Also, soluble MICB serum levels were associated with various diseases such as multiple sclerosis, liver diseases, cancers and rheumatoid arthritis.
Version 3 - 07.19
For research use only
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