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Murine IL-6 ELISA Kit

Product Specifications

Catalogue N°
860.020.048 - 1 x 48 Discovery (pre-coated)
860.020.096 - 1 x 96 (pre-coated)
860.020.192 - 2 x 96 (pre-coated)
Assay Range
15.6 pg/ml - 500 pg/ml
Sensitivity
10 pg/ml
Target species
Murine
Specificity
Recognizes both natural and recombinant murine IL-6
Incubation
3h45
Sample Type
Serum, Cell culture supernatant
Sample Size
100 µl
Cross Reaction
No cross reactivity with other murine cytokines
Kit Content
Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.
mIL-6 ELISA Kit
mIL-6 ELISA Kit

BACKGROUND

Interleukin-6 (IL-6) is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis and may play a central role in host defense mechanisms.

This cytokine is involved in :

  • the induction of B-cell differentiation,
  • the induction of acute phase proteins in liver cells,
  • growth promotion of myeloma/plasmacytoma/hybridoma cells,
  • induction of IL-2 and IL-2 receptor expression,
  • proliferation and differentiation of T cells,
  • inhibition of cell growth of certain myeloid leukemic cell lines and induction of their differentiation to macrophages,
  • enhancement of IL-3-induced multipotential colony cell formation in hematopoietic stem cells and induction of maturation of megakaryocytes as a thrombopoietic factor,
  • induction of mesangial cell growth,
  • induction of neural differentiation of PC cells
  • induction of keratinocyte growth.

The abnormal production of IL-6 was first suggested to be related to polyclonal B-cell activation with autoantibody production in patients with cardiac myxoma. Since then, IL-6 has been suggested to be involved in the pathogenesis of a variety of diseases. Measurement of IL-6 levels in serum and other body fluids thus provides more detailed insights into various pathological situations.

Version 15 - 02.20

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

860.020.048 1 x 48 Discovery (pre-coated)
860.020.096 1 x 96 (pre-coated)
860.020.192 2 x 96 (pre-coated)

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