- Catalogue N°
- 855.520.000 - 200µg / 200µl
855.520.005 - 500µg / 500µl
- Target species
- Recognises both natural and recombinant human MICB
- Flow Cytometry
- Myeloma X63/AG.8653 x Balb/c node cells
- Recombinant human MICB
- 200µg or 500µg (Discovery Size also available please enquire)
- Mouse IgG1 Kappa light chain
- Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within the MHC class I region of chromosome 6. Similar to MICA, MICB protein interacts with the natural killer cell receptor NKG2D and T cell receptor (TCR) and consequently activates the natural killer (NK) cells, gamma-delta (γδ) T cells and alpha-beta (αβ) CD8+ T cells, enhancing their cytolytic ability and cytokine production. Thus, the MICA/B–NKG2D pathway is an important mechanism by which the host immune system recognizes and kills transformed cells. This protein is stress and heat shock-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. It seems to have no role in antigen presentation.
In contrast to classical MHC class I molecules, MICA/B are expressed rarely on normal cells but frequently on tumor cells, including colon cancer, prostate cancer, hepatocellular carcinoma, and brain tumors. Also, soluble MICB serum levels were associated with various diseases such as multiple sclerosis, liver diseases, cancers and rheumatoid arthritis.
Version 7 - 08.19
For research use only
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