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Anti-Human MICB Azide Free

Product Specifications

Catalogue N°
855.520.000 - 200µg / 200µl
855.520.005 - 500µg / 500µl
Target species
Recognises both natural and recombinant human MICB
Flow Cytometry
Myeloma X63/AG.8653 x Balb/c node cells
Recombinant human MICB
200µg or 500µg (Discovery Size also available please enquire)
Mouse IgG1 Kappa light chain
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Anti-Human MICB Azide Free
A typical staining pattern with the B-D54 monoclonal antibody of JM cell line


MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within the MHC class I region of chromosome 6. Similar to MICA, MICB protein interacts with the natural killer cell receptor NKG2D and T cell receptor (TCR) and consequently activates the natural killer (NK) cells, gamma-delta (γδ) T cells and alpha-beta (αβ) CD8+ T cells, enhancing their cytolytic ability and cytokine production. Thus, the MICA/B–NKG2D pathway is an important mechanism by which the host immune system recognizes and kills transformed cells. This protein is stress and heat shock-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. It seems to have no role in antigen presentation.

In contrast to classical MHC class I molecules, MICA/B are expressed rarely on normal cells but frequently on tumor cells, including colon cancer, prostate cancer, hepatocellular carcinoma, and brain tumors. Also, soluble MICB serum levels were associated with various diseases such as multiple sclerosis, liver diseases, cancers and rheumatoid arthritis.

Version 7 - 08.19

For research use only


For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

855.520.000 200µg / 200µl
855.520.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human MICB Azide Free 855.520.000 - 200µg / 200µl 855.520.005 - 500µg / 500µl )

Please contact us to discuss bulk orders