- Catalogue N°
- 855.470.000 - 200µg / 200µl
855.470.005 - 500µg / 500µl
- Target species
- Recognises both natural and recombinant human IL-33
- Myeloma X63/AG.8653 x Balb/c node cells
- Recombinant human IL-33/NF-HEV
- 200µg or 500µg (Discovery Size also available please enquire)
- Mouse IgG1 Kappa light chain
- Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Interleukin-33 is described as a IL1 family cytokine which have important functions in host defense, immune regulation and inflammation. It is synthesized as a 30kD precursor ; then cleaved by caspase-1 to generate a 18kD fragment, termed mature IL-33.
IL-33 was originally identified as a protein abundantly expressed in endothelial cells of high endothelial venules (HEVs) and was previously named NF-HEV (nuclear factor in HEV). High level of IL-33 were also found in fibroblastic reticular cells of lymphoid tissues and certain types of epithelium, including skin keratinocytes and epithelial cells of stomach.
IL-33 induce T helper (Th) type 2 responses by signaling through the IL-1 receptor related protein ST2. Acts as Th2 chemotactic factor, also promots cytokine production (such as IL-6, IL-13, IL-1b, TNFa), IL-33 has also a role in activating basophil cells and regulating their migration.
It is recognized as important contributors to allergic inflammation by eosinophils cells activation and degranulation.Also contributes to hyperresponsivness reaction observed in asthma when secreted by ephitelial cells.
Version 6 - 06.19
For research use only
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