Anti-Human CD62P Azide Free

Product Specifications

Catalogue N°

855.390.000 - 200µg / 200µl
855.390.005 - 500µg / 500µl

Target species

Human

Specificity

Recognises both natural and recombinant CD62P

Clone

B-G43

Application

ELISA

Hybridoma

Myeloma X63/AG.8653 x Balb/c spleen cells

Immunisation

Recombinant human CD62P

Quantity

200µg or 500µg (Discovery Size also available please enquire)

Isotype

Mouse IgG2b Kappa light chain

Format

Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free

Storage

Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Synonym

P-Selectin

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BACKGROUND

P-selectin (CD62P, LECAM-3) was originally purified from platelets and later found to be expressed also in endothelial cells. In both cell types, P-selectin is constitutively expressed and stored in secretory granules – α-granules in platelets and Weibel-Palade bodies in endothelial cells.

A soluble form of P-selectin, which might represent a proteolytic fragment or a soluble splice variant lacking the transmembrane domain, is found in serum and plasma. High expression of P-selectin or sP-selectin has been implicated in several inflammatory disorders, including adult respiratory distress syndrome, acute lung injury, ischemia-reperfusion injury, Gram-negative septic shock, thrombotic diseases, malaria, systemic sclerosis, connective tissue disease and rheumatoid arthritis. Furthermore, lung injury scores correlate significantly with sP-selectin in plasma of patients with acute lung injury.

Version 6 - 06.19

For research use only

Documents

• Safety Data Sheet Mab Azide Free

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