Anti-Human MICA Azide Free
Product Specifications
- Catalogue N°
- 855.380.000 - 200µg / 200µl
855.380.005 - 500µg / 500µl - Target species
- Human
- Specificity
- Recognises both natural and recombinant human MICA
- Clone
- B-N31
- Application
- ELISA
- Hybridoma
- Myeloma X63/AG.8653 x Balb/c spleen cells
- Immunisation
- Recombinant human MICA
- Quantity
- 200µg or 500µg (Discovery Size also available please enquire)
- Isotype
- Mouse IgG1 Kappa light chain
- Format
- Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
- Storage
- Stable at +2-8°C for 12 months. DO NOT FREEZE.
BACKGROUND
MICA is a transmembrane glycoprotein that functions as a ligand for human NKG2D, an activating receptor expressed on NK Cells, NKT Cells, dg T-cells and CD8+ba T-cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effectors cells. MICA recognition is involved in tumour surveillance, viral infections, and autoimmune diseases.
Major histocompatibility complex (MHC) class I chain-related gene A and B (MICA and MICB) are transmembrane glycoproteins that function as ligand for NKG2D. These two proteins possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with b2-microglobulin. The genes encoding MICA/B are found within the MHC on human chromosome 6.
MICA and MICB have no role in antigen presentation but function as signal of cellular distress and interact with NKG2D-DAP10, the activating receptor.They are frequently expressed in epithelial tumour and may promote anti tumour NK and T-cell response.
Intestinal cells express MICA/MICB which are up-regulated under stress and in many gastrointestinal tumours. Release of MIC molecules from the cell surface is thought to constitute in immune escape mechanism of tumour cells.
MICA/MICB expression is elevated in the sera of patients with colorectal carcinoma and widely expressed in prostate carcinoma : MICA/MICB may be a novel biomarker for prostate cancer and its expression is also used as a monitor in Crohn’s disease.
Version 7 - 09.23
For research use only
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