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Anti-Human IL-8 PE Conjugated

Product Specifications

Catalogue N°
855.082.019 - 100 tests / 1ml
Target species
Human
Specificity
Recognises both natural and recombinant human IL-8
Clone
B-K8
Application
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human IL-8
Quantity
100 Tests / 1ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline with 5% BSA and 0,1% sodium azide
Storage
Stable at +2-8°C for six months after reconstitution. DO NOT FREEZE.
Working Dilution
Reconstitute with 1ml of deionized water. It is recommended to establish the optimal dilution according to the system being used. Use 10 μl of antibody to label 5.105 cells
Anti-Human IL-8 PE Conjugated
A typical staining pattern with the B-K8 monoclonal antibody of LPS activated MNC

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly


BACKGROUND

Interleukin 8 (IL-8) or CXCL8, Monocyte-Derived Neutrophil Chemotactic Factor (MDNCF), Neutrophil Activating Factor (NAF) and NAD-P1 is a chemokine secreted by monocytes, macrophages and endothelial cells. IL-8 chemoattracts and activates neutrophils.

The predominant form of IL-8 is a 8.4kDa protein containing 72 amino acid residues, which includes five additional N-Terminal amino-acids. IL-8 contains the four conserved cysteine residues present in CXC chemokines and also contains the “ELR” motif common to CXC chemokines that binds to CXCR1 and CXCR2.

Data indicate that IL-8 may participate in the pathogenesis of rheumatoid arthritis via the induction of neutrophil-mediated cartilage damage, and psoriasis. A causative involvement of IL-8 is found within a broad range of clinico-pathological conditions : adult respiratory distress syndrome, asthma, bacterial infections, bladder cancer, graft rejection and influenza infection, due to the now known biological properties of IL-8. This cytokine especially in combinations with other neutrophil activating agents, may prove helpful in the treatment of patients suffering from granulocytopenia, severe infections against which antibiotics are not effective, and immunodeficiency caused by HIV.

Version 9 - 06.19

For research use only

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Formats Available

855.082.019 100 tests / 1ml

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