Anti-Human IL-17A PE Conjugated

Product Specifications

Catalogue N°

853.942.019 - 100 tests / 1ml

Target species

Human

Specificity

Recognizes both natural and recombinant IL-17A

Clone

B-A50

Application

Flow Cytometry

Hybridoma

Myeloma X63/AG.8653 x Balb/c node cells

Immunisation

Recombinant human IL-17A

Quantity

100 Tests / 1ml (Discovery Size also available please enquire)

Isotype

Mouse IgG2b Kappa light chain

Format

Phosphate-buffered saline with 5% BSA and 0.1% sodium azide

Storage

Stable at +2-8°C for six months after reconstitution. DO NOT FREEZE.

Working Dilution

Reconstitute with 1 ml deionised water. Use 10 μl to label 10⁶ cells or 100 μl of whole blood

• References
• Related products

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly

BACKGROUND

Interleukin-17 (IL-17, or IL-17A) is the founding member of a group of cytokines called the IL-17 family. IL-17A, was originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993.

IL-17A is involved in inducing and mediating proinflammatory responses, commonly associated with allergic responses and induces the production of many other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α and MCP-1) and prostaglandins (e.g. PGE2) from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages).

IL-17A function is also essential to a subset of CD4+ T-Cells called T helper 17 (Th17) cells.

Version 6 - 03.21

For research use only

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