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Anti-Human CD106 Unconjugated

Product Specifications

Catalogue N°
853.823.020 - 200 tests / 2ml
Target species
Human
Specificity
Recognises the Vascular Cellular Adhesion Molecule-1 (VCAM-1), a 110 kDa protein
Clone
B-S6
Application
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Activated human umbilical vein endothelial cells
Quantity
200 Tests / 2ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline with 1% BSA and 0.09% sodium azide
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Working Dilution
Use 10 μl to label 106 cells or 100 μl of whole blood
Synonym
VCAM-1
Anti-Human CD106 Unconjugated
A typical straining pattern obtained with the clone B-S6 (red line) on T-lymphoma cell line HUT78 compared to the isotype control (black line).

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly


BACKGROUND

The vascular cell adhesion protein 1, also known as vascular cell adhesion molecule 1 (VCAM-1) or differentiation group 106 (CD106), is a protein that in humans is coded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.

The VCAM-1 protein induces the adhesion of lymphocytes, monocytes, eosinophils and basophils to the vascular endothelium. It also plays a role in signal transduction of leukocyte-endothelial cells and may play a role in the development of atherosclerosis and rheumatoid arthritis.

Positive regulation of VCAM-1 in endothelial cells by cytokines results from increased transcription of the gene (eg, in response to tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1 )) and the stabilization of the messenger RNA. (MRNA) (e.g., interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem sites NF-KB (nuclear factor-kappa B). The sustained expression of VCAM-1 lasts more than 24 hours.

Mainly, the VCAM-1 protein is an endothelial ligand of the VLA-4 (Very Late Antigen-4 or α4β1 integrin) of the β1 integrin subfamily. VCAM-1 expression has also been observed in other cell types (eg, smooth muscle cells). It has also been shown to interact with EZR and Moesin.

CD106 also exists on the surface of certain sub-populations of mesenchymal stem cells (MSCs).

Version 2 - 06.19

For research use only

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Formats Available

853.823.020 200 tests / 2ml

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