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Anti-Human Perforin Azide Free

Product Specifications

Catalogue N°
853.640.000 - 200µg / 200µl
853.640.005 - 500µg / 500µl
Target species
Human
Specificity
Recognizes human Perforin, a 70 kDa protein
Clone
B-E48
Application
ELISA
ELISpot
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Natural human Perforin
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG2b Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

BACKGROUND

Perforin is involved in the killing function by CTLs and NKs. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. It leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis, the cell death program.

Perforin has structural and functional similarities to complement component 6, 7, 8 and 9 (C6, C7, C8, C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.

Perforin is a 70kDa protein containing 534 amino acid.

Its role in the immune response against tumors and virus infection has been demonstrated.

Version 7 - 06.19

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

853.640.000 200µg / 200µl
853.640.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email:

Please contact us to discuss bulk orders