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Anti-Human CD264 Azide Free

Product Specifications

Catalogue N°
853.130.000 - 200µg / 200µl
853.130.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises TRAIL R4 (DcR2), a 44.2 kDa protein
Clone
B-P30
Application
Immuno-Precipitation
Western Blot
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL R4/Fc chimera
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months
Synonym
DcR2
TRAIL R4

BACKGROUND

Human Trail R4, also called DcR2, CD264 or TRUNND is a type 1 TNF R family membrane protein which is a receptor for TRAIL. In the Trail receptor family, Trail R4 (DcR2) but also Trail R3 (DcR1) antagonize TRAIL-induced apoptosis whereas Trail R1 (DR4) and Trail R2 (DR5) transducer an apoptosis signal. Trail R4 has a truncated intracellular domain.  Overexpression of Trail R4 has been shown to protect cells bearing Trail R1 and/or Trail R2 from Trail-induced apoptosis. Many tumor cell lines don’t express the decoy receptors and are therefore sensitive to TRAIL if they express Trail R1 and/or Trail R2.

Version 11 - 04.20

For research use only

Documents

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Formats Available

853.130.000 200µg / 200µl
853.130.005 500µg / 500µl

Ordering options

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