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Human IFN-γ ELISA Set

Product Specifications

Catalogue N°
851.560.001 - 1 x 96 Discovery
851.560.005 - 5 x 96
851.560.010 - 10 x 96
851.560.015 - 15 x 96
851.560.020 - 20 x 96
Assay Range
12.5 pg/ml - 400 pg/ml
Sensitivity
5 pg/ml
Target species
Human
Specificity
Recognizes both natural and recombinant human IFN-g
Incubation
From sample to end 2h45
Sample Type
Serum, Plasma, Cell culture supernatant
Sample Size
100 µl
Cross Reaction
No cross reactivity with other human cytokines. Cross reactivity with simian IFN-g.
Kit Content
Diaclone ELISA Sets include capture and biotinylated detection antibody, one standard per plate, Streptavidin-HRP, TMB, and detailed procedure including buffer composition.
Synonym
IFN-g
IFN-gamma

BACKGROUND

Interferon-gamma (IFN-γ, IFN-g, IFN gamma), also known as type II or immune interferon, is a dimerized soluble cytokine.

Interferon gamma is produced mainly by activated T cells and Natural Killer cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops. IFN gamma is also produced by non-cytotoxic innate lymphoid cells (ILC), a family of immune cells first discovered in the early 2010s

IFNg is considered to be a proinflammatory cytokine, that activates macrophages and endothelial cells, it also regulates immune responses by effecting APC, T and  cells.

IFN gamma is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFN gamma is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression. Aberrant IFNγ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects.

Version 12 - 07.19

For research use only

Documents

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Formats Available

851.560.001 1 x 96 Discovery
851.560.005 5 x 96
851.560.010 10 x 96
851.560.015 15 x 96
851.560.020 20 x 96

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