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Human CD86 ELISA kit

Product Specifications

Catalogue N°
850.590.048 - 1 x 48 Discovery (pre-coated)
850.590.096 - 1 x 96 (pre-coated)
850.590.192 - 2 x 96 (pre-coated)
Assay Range
1.187 U/ml - 38 U/ml
Sensitivity
0.6 U/ml
Target species
Human
Specificity
Recognizes natural human soluble CD86
Incubation
2h40
Sample Type
Serum, Plasma, Cell culture supernatant
Sample Size
100 µl
Cross Reaction
No cross reactivity with other human soluble molecules
Kit Content
Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.
Synonym
B7-2
CD86 ELISA Kit
CD86 ELISA Kit

BACKGROUND

CD86 (also known as B7-2) is a transmembrane glycoprotein member of the IgG superfamily. CD86 is expressed on antigen-presenting cells that provide co-stimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 (B7-1) to prime T cells and its co-stimulatory pathway plays an important role in the development of anti-tumour response.

Some studies have shown that CD86 expression by malignant cells is associated with a poor prognosis in both acute myeloid leukemia and multiple myeloma and a decrease of CD86 on PBM in melanoma results in an ineffective immune response.

A high level of soluble CD86 in plasma was described in several diseases: abdominal aortic aneurysm, leukaemia, systemic lupus erythematosus and acute asthma.

Version 7 - 07.19

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

850.590.048 1 x 48 Discovery (pre-coated)
850.590.096 1 x 96 (pre-coated)
850.590.192 2 x 96 (pre-coated)

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