- Catalogue N°
- 851.680.001 - 1 x 96 Discovery
851.680.005 - 5 x 96
851.680.010 - 10 x 96
851.680.015 - 15 x 96
851.680.020 - 20 x 96
- Assay Range
- 6.25 pg/ml - 200 pg/ml
- 3 pg/ml
- Target species
- Recognizes both natural and recombinant human IL-7
- From sample to end 2h45
- Sample Type
- Serum, Plasma, Cell culture supernatant
- Sample Size
- 100 µl
- Cross Reaction
- No cross reaction with other human cytokines
- Kit Content
- Diaclone ELISA Sets include capture and biotinylated detection antibody, one standard per plate, Streptavidin-HRP, TMB, and detailed procedure including buffer composition.
Human IL-7 (Interleukin 7, IL-7) is a 177-amino acids protein encoded by the IL7 gene located on chromosome 8 (Locus 8q12-13). The active form is glycosylated, weight 25kDa and binds to the IL-7 receptor, a heterodimer consisting of Interleukin-7 receptor alpha (CD127) and common gamma chain receptor CD132) Interleukin-7 is a member of hematopoietic growth factor which plays a role in T-cells development and induces the growth of immature B lymphocytes. IL-7 is secreted by epithelial cells in thymus and bone marrow. It is also produced by intestinal epithelium, keratenocytes, hepatocytes and dendritics cells. It was described to regulate T cell response and proliferation in tissue and serve as a potent regulatory factor.
IL-7 is known to induce the differentiation and proliferation of some haematological malignancies including certain types of leukaemias, lymphomas and may be elevated in lymphopenia. It was also described in breast cancer, common variable immunodeficiency (CVID), HIV (originally presented as a potential eradicating agent), rheumatoid arthritis.
In invasive breast cancer, an aberrant expression of IL-7 and its signaling were described.
In CVID, an elevated plasma levels of circulating IL-7 in a subgroup of patients.
In HIV, it was described that an increase of IL-7 level, produced by dendritic-like cells, enhances a lymphocytes depletion in tissues (lymphopenia).
In RA, IL-7 in synovial fluid activates T cells and macrophages which lead to the inflammation characteristic of RA thought TNFα.
Version 8 - 07.19
For research use only
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