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Anti-Human IL-29 Azide Free

Product Specifications

Catalogue N°
855.880.000 - 200µg / 200µl
855.880.005 - 500µg / 500µl
Target species
Human
Specificity
Recognizes both natural and recombinant human IL-29
Clone
B-Z29
Application
ELISA
Hybridoma
Myeloma X63/AG.8653 x Balb/c node cells
Immunisation
Recombinant human IL-29
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG2a Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Synonym
Interferon lambda 1
ZCYTO21

BACKGROUND

IL-29 was discovered in 2003. Also termed IFNl1, IL-29 belongs to the type III subset of IFN family with IL-28A and IL-28B, respectively IFNl2 and IFNl3. The IFNl genes are clustered together on human chromosome 19 and are composed of multiple exons, resembling the structural organization of genes encoding IL-10-related cytokines. The IL-29 gene encodes 20 kDa secreted monomeric protein.

The IFNl proteins bind and signal through a heterodimeric receptor composed of the unique IFNlR1 chain (also known as IL-28RA) and the shared IL-10Rb chain which is also a part of the receptor for IL-10, IL-22. IFN type I receptors are largely restricted to cells of epithelial origin. They activate the same intracellular signaling pathway and trigger many of the same biological activities, including antiviral and antitumor activity, in a wide variety of target cells.

IL-29 plays a role in the antiviral defence, predominantly in the epithelial tissues. It has been described as a therapeutic agent to treat patients with chronic hepatitis C virus by inhibiting B and C hepatitis virus replication.

It could be the main inhibitor to innate immunity and has demonstrated activity at the interface between innate and adaptive immunity. IFNl inhibits also the Th2 response and acts directly on CD4+ T-Cells and dendritic cells, effects are not accompanied by a complementary elevation of Th1.

Its use as a potential therapeutic agent for allergic asthma is under study and its anti-proliferative and anti-tumor activities make it a novel target for the treatment and control of some cancer.

Version 5 - 06.19

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

855.880.000 200µg / 200µl
855.880.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human IL-29 Azide Free 855.880.000 - 200µg / 200µl 855.880.005 - 500µg / 500µl )

Please contact us to discuss bulk orders