Human IL-1α ELISA Set
Product Specifications
- Catalogue N°
- 851.600.001 - 1 x 96 Discovery
851.600.005 - 5 x 96
851.600.010 - 10 x 96
851.600.015 - 15 x 96
851.600.020 - 20 x 96 - Assay Range
- 31.25 pg/ml - 1000 pg/ml
- Sensitivity
- 10 pg/ml
- Target species
- Human
- Specificity
- Recognizes both natural and recombinant human IL-1a
- Incubation
- From sample to end 3h45
- Sample Type
- Serum, Plasma, Cell culture supernatant
- Sample Size
- 100 µl
- Cross Reaction
- No cross reactivity with other human cytokines
- Kit Content
- Diaclone ELISA Sets include capture and biotinylated detection antibody, one standard per plate, Streptavidin-HRP, TMB, and detailed procedure including buffer composition.
- Synonym
- IL-1a
- IL-1alpha
BACKGROUND
In fact, there is not one molecule, but one family of IL-1 molecules comprising 11 members, the two most studied forms of interleukin-1 being:
IL-1α
IL-1β, its main form, involved in the reaction cascade comprising different molecules described under the name of inflammasome.
These two forms of IL-1 generally bind to the same cellular receptor, which is composed of two related but non-identical subunits, which transmit intracellular signals via a pathway mainly shared with other receptors, such as those of the Toll1 family (innate immunity receptors) and the IL-18 receptor. Stimulation of the receptor results in the secretion or synthesis of several inflammatory mediators.
The IL-1 receptor antagonist, IL-1Ra, binds to the same membrane receptor as IL-1, and prevents IL-1 from sending its signal to the cell. It is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. It is commercially produced as anakinra, which is a recombinant human form of IL-1Ra. Interleukin 1 (IL-1) is a cytokine secreted by macrophages, monocytes and dendritic cells. It plays a preeminent role in the inflammatory response of the body to infections.
Version 5 - 07.19
For research use only
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